Adaptación del famoso videojuego de Rockstar.
Max Payne (Mark Wahlberg) es un policía heterodoxo –un antihéroe mítico– decidido a dar con los responsables de los brutales asesinatos de su familia y de su compañera. Resuelto a vengarse caiga quien caiga, su obsesiva investigación le lleva a embarcarse en una odisea de pesadilla rumbo al tenebroso mundo del hampa. A medida que el misterio va aumentando, Max se ve obligado a combatir con enemigos de más allá del mundo natural y a enfrentarse con una traición inconcebible.

Three years ago, NYPD detective Max Payne's wife and baby were murdered. Max gets himself transferred to the cold case office where he can continue searching for the killer who got away. He's a loner, but two people reach out to him during a fateful week: Alex, his ex-partner who may have found a clue, and BB, the security chief at the pharmaceutical company where Max's wife worked. Meanwhile, bodies are piling up, some as a result of a drug on the street that is highly addictive and, for many who take it, brings hideous hallucinations. When one of the bodies is a woman Payne was the last to see alive, her sister comes looking for him armed to the teeth; Max must move fast.