Una pareja de enfermos terminales de cáncer deciden hacer un último viaje para poder realizar todas las cosas que desean hacer antes de morir. Después de escarpar de una sala para enfermos de cáncer, inician un viaje que les llevara a participar en carreras de coches, comer ingentes cantidades de caviar y jugar al póquer en Monte Carlo.

Corprate billionaire Edward Cole and working class mechanic Carter Chambers have nothing in common except for their terminal illnesses. While sharing a hospital room together, they decide to leave it and do all the things they have ever wanted to do before they die according to their bucket list. In the process, both of them heal each other, become unlikely friends, and ultimately find the joy in life.