Una escalofriante ola de atracos está teniendo lugar en Nueva York. La policía no tiene sospechosos y lo más misterioso de todo es que los criminales son invisibles y absolutamente silenciosos. Los únicos capaces de mantener el orden son unas simpáticas tortugas ninja mutantes que corresponden a los nombres de Donatello, Leonardo, Raphael y Michaelangelo.

Through contact with a mysterious substance, called Ooze, 4 little turtles in the canalization of New York mutate to giant turtles. They can speak, walk upright and love pizza. The wise rat Splinter becomes their mentor and educates them to Ninja fighters. Their arch-enemy is the bad, bad guy Shredder, who struggles to gain power over the world. Of course the ninja turtles will do everything to stop him.