Basada en el célebre cómic de Frank Miller y co-dirigida por Robert Rodriguez y el propio Miller, nos llega una película transgresora que cuenta con un gran elenco de actores y la colaboración especial del director Quentin Tarantino, Bruce Willis interpreta a Hartigan, un policía que trata de proteger a una bailarina exótica. Mickey Rourke es Marv, un ex convicto que pretende vengar la pérdida de su único amor. Clive Owen como Dwight, es un investigador privado que se dedica a proteger a sus amigas, las damas de la noche, del corrupto policía que las asedia, Jack (Benicio del Toro). Basin City es una ciudad donde reina la corrupción, unos buscan venganza, otros redención y algunos las dos cosas...

"Sin City" is four stories inter-weaved telling tales of corruption in Basin City. The first story (The Customer is always right) is short, and is based on the depression of women that they need to pay a man to feel loved when they commit suicide. The next story is Part 1 of "That Yellow Bastard" about a cop who needs to save a young girl from being raped. The third story (The Hard Goodbye) features a man taking revenge on a heartless killer who murdered his one-night stand. The fourth story (The Big, Fat Kill) stars a man who must dispatch a cop's body, but it will be a tough ride to do it. Following that are two conclusions to Sin City, the ending of "That Yellow Bastard" which is set 8 years later, and a short story that ends Sin City.