Varias mujeres desaparecen en una población rural de Virginia. Un sacerdote que tiene "visiones" mandará a la policía a un lugar concreto, donde encontrarán una serie de fosas con cuerpos humanos congelados que parece ser un experimento médico secreto y que puede tener relación con las mujeres desaparecidas... Vuelven los agentes del FBI Mulder y Scully, protagonistas de una de las series más populares de la historia de la televisión. Dirigida por el propio creador de la serie, Chris Carter, una nueva adaptación cinematográfica que se puede ver de forma independiente, sin necesidad de estar familiarizado con la popular serie de TV.

Fox Mulder and Dana Scully both worked at the FBI as partners, a bond between them that led to their becoming lovers. But now they're out of the FBI and have gone their separate ways. Scully works as a staff physician at a Catholic hospital. Her focus these days is on a young boy with an incurable brain disease. Administration wants to give up on him. Scully, who feels a special bond with the boy, does not. Meanwhile, Mulder's focus is on clipping newspaper articles about the paranormal and throwing pencils into his ceiling. Scully and Mulder are brought together again when a special case requires Mulder's expertise, and Scully is prevailed upon to find him. The case involves a pedophile priest who claims he is having psychic visions regarding the whereabouts of a missing FBI agent.