Shelley (Anna Faris) lleva una vida sin preocupaciones hasta que es expulsada de la Mansión Playboy. Sin ningún sitio donde ir, el destino la introduce en las vidas de un grupo de chicas universitarias poco integradas socialmente que perderán su residencia universitaria si no logran atraer a nuevos miembros. Para que consigan su objetivo, Shelley tiene que usar todos sus trucos y darles un curso intensivo sobre maquillaje y sobre hombres.

Finding family. Shelley Darlingson was raised in an orphanage, finally happy when she blossoms into a fox and moves into the Playboy Mansion. Unfortunately, she's summarily expelled on her 27th birthday(she's now too old). In desperation she takes a job as house mother for a sorority of misfits losing their house for lack of members. They have but a few months to find 30 pledges, or a sorority of mean girls will take over their place. Shelley figures that girls will pledge a house that boys find interesting, so she sets out to make the Zetas alluring, not act too smart, and host great parties. Can she succeed, and what about her own makeover? Sabotage is everywhere, plus it's hard to be one's self.