Una de las partes de Grindhouse junto con Planet Terror de Robert Rodriguez. Stuntman Mike (Kurt Russel) es un rebelde malencarado que sólo se siente compelto cuando se encuentra tras el volante de su mastodóntico coche. Juntos, el coche y Mike, se convierten en un arma letal: recorren las carreteras en busca de hermosas mujeres que se convierten en víctimas de su sed de sangre.

Stuntman Mike is a former Hollywood stunt race car driver who targets and kills women with his "death-proof" stunt car. In Act I, Mike surfaces in Austin, Texas to target a group of women whom he knows; Jungle Julia an outgoing, dope-smoking, radio DJ/fashion model meeting her old school friends for a night on the town whom are sentimental model Arlene, and local bad-girl Shanna, as well as bar-nut hippie Pam who tries to make Mike notice her, unaware of his sociopath and misogynist tendencies. In Act II, Stuntman Mike surfaces in Tennessee where he randomly picks another another group of women to stalk all of whom work in the motion picture business; Abernathy is a make-up girl and stand-in wanting a change of pace in her life. Lee is a naive B-movie actress. Kim is a tough-minded stunt woman always wanting action. And Zoe is a fellow stunt woman from New Zealand visiting her friends. However, the second set of girls proves more though to get, and because of a combination of bad luck and Stuntman Mike's carelessness, the girls decide to turn the tables on their tormentor for revenge of their own...